Abcam, ab131117, Anti-GPCR GPR101 antibody

Size: 50µL
Rabbit Polyclonal GPCR GPR101 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR101.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GPR101. The exact immunogen used to generate this antibody is proprietary information.Q96P66

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR101 also known as G-protein coupled receptor 101 is a complex transmembrane protein that belongs to the GPCR family. As a GPCR it plays an important role in signal transduction by interacting with G-proteins upon activation by a ligand. This receptor has a molecular mass of approximately 56.4 kDa. GPR101 is expressed in variable levels across several human tissues with high expression noted in the brain particularly in the pituitary and hippocampus regions.
Biological function summary
The role of GPR101 involves promoting cellular responses to external signals leading to changes in cellular activity. It does not typically associate with larger protein complexes but interacts directly with G-proteins to mediate its functions. Research suggests GPR101 predominantly influences brain signaling pathways possibly affecting neurological processes and development.
Pathways
GPR101 integrates into key signaling routes by facilitating the activation of adenylate cyclase through G-protein signaling. This pathway plays a significant role in the control of cyclic AMP (cAMP) levels an important secondary messenger involved in several cellular processes. It shares pathway space with other GPCRs such as GPR161 which also influences cAMP signaling. Through these pathways GPR101 contributes to the regulation of neuronal signaling and potential growth factors.
GPR101 has been linked to certain growth disorders particularly gigantism. Abnormal expression or mutations in this receptor are associated with excessive growth hormone release. It is also connected to pituitary adenomas where its overexpression might contribute to tumor pathogenesis. Other GPCRs like GPR4 may also display dysregulation in similar conditions indicating a network of GPCR involvement in such disorders.