Abcam, ab131135, Anti-Cadherin like 23 antibody

Size: 50µg
Rabbit Polyclonal Cadherin like 23 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cadherin like 23 also known as CDH23 or otocadherin is a protein with a mass of approximately 335 kDa. This protein is a member of the cadherin superfamily and acts mechanically to mediate calcium-dependent cell-cell adhesion. It is important for maintaining the structure and function of hair cells in the inner ear where it is highly expressed. Additionally CDH23 is present in other tissues such as the retina highlighting its role in sensory organs.
Biological function summary
Cadherin like 23 contributes to the organization and maintenance of stereocilia which are actin-filled protrusions important for mechanotransduction in cochlear hair cells. CDH23 forms part of the tip link complex that connects stereocilia enabling the conversion of mechanical stimuli into electrical signals. Its involvement in forming this complex illustrates its essential role in auditory function and cellular communication.
Pathways
Cadherin like 23 is involved in essential biological processes linked to calcium signaling and the auditory transduction pathway. It interacts with other proteins such as myosin VIIA and protocadherin 15 which are critical for hair cell function and hearing. The protein plays a role in the mechanotransduction channel activity contributing to the regulation of ion influx that triggers auditory perception.
Mutational defects in Cadherin like 23 have been associated with Usher syndrome type 1D and non-syndromic sensorineural deafness (DFNB12). CDH23 mutations lead to disrupted hair cell function resulting in hearing loss and balance disorders frequently seen in these conditions. The protein's connection to disease also involves another cadherin-related protein protocadherin 15 which shares overlapping roles in similar cellular pathways highlighting the intricate interplay of these proteins in auditory-related genetic disorders.