Abcam, ab131253, Anti-FBP2 antibody [EPR7436]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FBP2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7436,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBP2 also known as fructose-16-bisphosphatase 2 is an enzyme that catalyzes the conversion of fructose-16-bisphosphate to fructose 6-phosphate. This reaction is important for the process of gluconeogenesis. FBP2 weighs around 37.6 kDa and is expressed in various tissues including the liver and kidney where it supports energy metabolism by synthesizing glucose from non-carbohydrate precursors.
Biological function summary
The enzyme plays a role in glucose homeostasis by regulating gluconeogenesis. It is a part of the fructose-16-bisphosphatase complex that controls the balance between glycolysis and gluconeogenesis. FBP2 activity helps to maintain blood glucose levels particularly during periods of fasting or intense physical activity. By adjusting the rate of glucose production and consumption the enzyme contributes to metabolic flexibility.
Pathways
FBP2 functions in the regulation of the gluconeogenesis pathway. This pathway is key in maintaining normal blood glucose levels and the enzyme acts in coordination with related enzymes like glucose-6-phosphatase. FBP2 is involved in the balance between glycolysis and gluconeogenesis partnering with enzymes such as phosphofructokinase which perform opposite functions to regulate energy production and consumption. This fine-tuning of energy pathways ensures that cells have a stable supply of glucose adjusting for factors such as nutrient availability and hormonal signals.
FBP2 has connections to metabolic disorders like type 2 diabetes and glycogen storage diseases. Impaired FBP2 activity can disrupt glucose homeostasis leading to dysregulated blood sugar levels characteristic of type 2 diabetes. Additionally the activity of FBP2 can influence the function of other proteins like insulin receptor substrates impacting insulin signaling pathways. Dysfunctions in these pathways can exacerbate insulin resistance and metabolic syndromes emphasizing the significance of FBP2 in maintaining metabolic health.