Abcam, ab133237, Anti-Exportin 4/XPO4 antibody [EPR4442(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Exportin 4/XPO4 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4442(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Exportin 4 also known as XPO4 is a nuclear export receptor part of the karyopherin beta family. It has a molecular weight of approximately 130 kDa. This protein functions by mediating the transport of several cargo molecules from the nucleus to the cytoplasm engaging in the nucleocytoplasmic transport mechanism. Exportin 4 is expressed in various tissues but it shows a higher expression in tissues with active cell division such as the thymus. It specifically recognizes and binds to its cargo proteins in the presence of RanGTP facilitating their export through the nuclear pore complex.
Biological function summary
Exportin 4 plays an important role in the regulation of protein synthesis by exporting molecules involved in translation. It acts as part of a complex with RanGTP a small GTPase that provides the energy required for nuclear transport. This transport process is essential for maintaining cellular function and homeostasis by regulating the localization of proteins that are necessary for cell growth and division. The specificity of the cargo depends on its nuclear export signals which Exportin 4 recognizes with high affinity.
Pathways
Exportin 4 is integrated into the Ran pathway which is vital for nuclear import and export processes. In this pathway Exportin 4 transports proteins necessary for cell cycle progression and gene expression. A related protein in this pathway is RanBP1 which assists in the dissociation of the export complex in the cytoplasm. Exportin 4 also interacts with other proteins like CRM1 to coordinate the export of specific RNA molecules impacting the balance of nuclear and cytoplasmic activities in the cell.
Alterations in Exportin 4 function can influence cancer progression and neurodegenerative diseases. Aberrant export activity can lead to mislocalization of tumor suppressor proteins contributing to oncogenesis. In neurodegenerative conditions such as Alzheimer’s disease Exportin 4 dysregulation affects neuronal function partly due to its interaction with Tau protein which can aggregate abnormally in neurons. Understanding the dynamics of Exportin 4 can therefore provide insights into therapeutic targets for these diseases.