Abcam, ab133558, Anti-CAP2 antibody [EPR6378]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CAP2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6378,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAP2 also known as Cyclase Associated Protein 2 is a protein playing an essential role in actin dynamics. It has a molecular mass of approximately 54 kDa. Researchers have detected its expression in various tissues including the heart skeletal muscle and brain. CAP2 influences the organization of the cytoskeleton by binding to actin filaments and regulating their polymerization and depolymerization. Its activity makes it an important player in cell motility and structure maintenance.
Biological function summary
CAP2 contributes to cellular processes by modulating actin filament turnover and facilitating actin recycling. It operates as part of a protein complex that includes other actin-binding proteins often working in tandem with profilin and cofilin. This complex formation is integral to the regulation of cytoskeletal organization impacting important cellular functions like cell division intracellular transport and signal transduction.
Pathways
CAP2 is an active participant in pathways controlling cell movement and structural integrity particularly the actin cytoskeleton signaling pathway. In this role CAP2 interacts with proteins such as cofilin which also modulates actin dynamics to maintain a balance of actin filament assembly and disassembly. Another pathway CAP2 is involved in is the cell adhesion pathway where it helps facilitate the dynamic remodeling necessary for cell attachment and migration.
CAP2 has been linked to cardiac diseases and cancer. Alterations in CAP2 expression have been associated with the development of dilated cardiomyopathy a condition marked by weakened heart muscle functionality. Furthermore CAP2 has demonstrated interactions with p53 a protein often mutated in cancers implicating it in processes that may contribute to tumor growth and metastasis. These connections reveal its importance not only in normal cellular function but also in pathological states.