Abcam, ab133621, Anti-ESE1 antibody [EPESER1]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ESE1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Rat, Mouse, Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPESER1,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This antibody was developed as part of a collaboration with the lab of Jim Hu at the University of Toronto.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ESE1 also known as ETS transcription factor ELK3 is a critical transcription factor belonging to the ETS family. This protein weighs approximately 43 kDa. ESE1 is highly expressed in epithelial tissues such as skin lung and breast. It plays an essential role in regulating gene expression by binding to specific DNA sequences and influencing transcriptional processes.
Biological function summary
ESE1 functions as a transcription activator and impacts cellular differentiation proliferation and apoptosis. It is part of a larger transcriptional complex involving additional co-activators and co-repressors. This transcription factor facilitates the control of genes tied to cell growth and development making its activity significant for normal cellular function.
Pathways
ESE1 interacts within the MAPK signaling and TGF-beta pathways influencing cellular responses to external stimuli. In the MAPK pathway ESE1 associates with proteins such as ERK1/2 to transmit signals from the cell membrane to the nucleus affecting cell fate decisions. In the TGF-beta pathway it supports regulatory mechanisms that control cell proliferation and differentiation.
Altered ESE1 expression is connected to breast cancer and psoriasis. In breast cancer ESE1 dysregulation may stimulate cancer cell growth and metastasis possibly through interaction with proteins like BRCA1 that are known for their roles in cell cycle regulation and DNA repair. In psoriasis changes in ESE1 function can lead to aberrant epidermal differentiation and inflammation further impacting the disease’s progression.