Abcam, ab133652, Anti-Dysbindin antibody [EPR7041]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Dysbindin antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7041,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dysbindin also known as Dystrobrevin Binding Protein 1 (DTNBP1) is an important protein that plays an important role in cellular processes. Its molecular weight is approximately 40 kDa. Dysbindin is expressed in a variety of tissues but it shows higher expression in the brain and testis. Within cells dysbindin localizes to the cytoplasm and is notably present at synaptic sites where it assumes an important function in neuronal communication.
Biological function summary
Multiple cellular processes involve dysbindin including synaptic transmission and intracellular signaling. Dysbindin is a component of the Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1) which is important for the biogenesis and trafficking of lysosome-related organelles. Its role in ensuring proper lysosomal function is linked to the regulation of synaptic vesicle release influencing neurotransmitter availability in synaptic clefts.
Pathways
Several important biological networks engage dysbindin particularly affecting neural and cellular functions. It participates in the synaptic vesicle cycle and pigment cell pathways. Dysbindin’s functional relationship with proteins such as Snapin and Pallidin illustrates its connection to BLOC-1-related pathways indicating its integrative role in synaptic endosome trafficking and pigment gene expression processes.
Dysbindin has a significant association with schizophrenia and Hermansky-Pudlak syndrome type 7. Genetic studies have linked the dysbindin gene to altered risk for schizophrenia through its impact on synaptic function and plasticity. Additionally its interaction with other BLOC-1 components like Pallidin ties it to Hermansky-Pudlak syndrome where disrupted organelle trafficking affects pigmentation and leads to systemic symptoms.