Abcam, ab133664, Anti-ACSS2 antibody [EPR8500]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ACSS2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 16 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8500,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACSS2 also known as acyl-CoA synthetase short-chain family member 2 plays an important role in acetate metabolism and energy generation. This enzyme is responsible for the conversion of acetate into acetyl-CoA an essential metabolite in cellular processes. ACSS2 has a molecular mass of approximately 73 kDa and its expression occurs mainly in liver brain and testis tissues highlighting its widespread physiological relevance.
Biological function summary
ACSS2 regulates cellular energy homeostasis by producing acetyl-CoA for energy production and biosynthetic reactions. This enzyme provides the necessary substrate for the synthesis of fatty acids cholesterol and acetylation of proteins impacting cellular metabolism and function. ACSS2 operates independently and does not form part of any known enzyme complex emphasizing its unique role in acetate utilization.
Pathways
ACSS2 functions as a central component of lipid metabolism and the acetyl-CoA positioned pathways. It integrates into the glycolysis-associated pathways when it contributes to the energy-producing acetyl-CoA pool. ACSS2 interacts with other metabolic enzymes like ATP citrate lyase in controlling the balance of acetyl-CoA production which is important for both lipid synthesis and energy metabolism.
Abnormalities in ACSS2 activity have links to conditions like cancer and metabolic syndrome. Alterations in the expression or function of ACSS2 can affect energy metabolism contributing to the growth and survival of cancer cells. Additionally the protein's dysregulation might play a role in metabolic syndrome associated with improper lipid and glucose homeostasis. ACSS2 interacts with oncogenes and metabolic regulators such as AMPK emphasizing its relevance in disease modulation.