Abcam, ab133681, Anti-SelM antibody [EPR8279]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SELM antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8279,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein SelM also known as selenoprotein M weighs approximately 14 kDa. SelM contains selenocysteine an amino acid incorporating selenium and is structurally small. Researchers identified SelM expression in various tissues including the brain liver and lungs. The exact cellular localization can vary according to the tissue type and the physiological conditions. SelM belongs to the family of selenoproteins which play numerous roles in redox homeostasis and enzyme regulation.
Biological function summary
SelM contributes significantly to intracellular antioxidant defense processes. It plays a role in maintaining the balance of reactive oxygen species (ROS) and protects cells from oxidative stress. Some findings suggest the association of SelM with protein complexes that combat oxidative damage although the specific interacting partners need further research. The protective function helps stabilize the cellular environment in challenging oxidative conditions.
Pathways
The selenoprotein SelM participates in antioxidant pathways such as the glutathione metabolic pathway. SelM may interact with other selenoproteins like GPx1 a glutathione peroxidase to help detoxify harmful peroxides. Furthermore SelM can be an integral component of cellular defense systems that maintain cell viability by controlling ROS levels and promoting a balanced redox state within cells.
SelM's role in oxidative stress management links it to neurodegenerative diseases such as Alzheimer's disease. Oxidative stress is a known factor in these diseases and SelM’s antioxidant function suggests potential protective effects. Evidence although limited implies a connection between SelM and proteins like amyloid precursor protein (APP) which could influence its pathogenicity in Alzheimer’s. Additionally disruptions in SelM expression or function might connect to metabolic disorders that involve oxidative damage. Further studies should clarify these relationships and ascertain SelM's therapeutic relevance.