Abcam, ab133768, Anti-ARF GAP 2 antibody [EPR8497]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ARF GAP 2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8497,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARF GAP 2 also known as ADP-ribosylation factor GTPase-activating protein 2 acts as a GAP protein that enhances the intrinsic GTPase activity of ARF proteins. This action helps modulate the ARF proteins' ability to switch between active and inactive forms which plays a role in their regulatory functions. ARF GAP 2 possesses a molecular weight of approximately 48 kDa and shows expression in various tissues particularly in brain heart and skeletal muscle tissues.
Biological function summary
ARF GAP 2 participates in the processes controlling vesicular trafficking and cytoskeletal dynamics. It interacts within a complex that manages the assembly and disassembly of actin structures which are important for cellular movement and shape changes. By influencing the ARF proteins it contributes to membrane trafficking and protein sorting essential for maintaining cellular organization and function.
Pathways
ARF GAP 2 integrates into the Arf-related signaling route and the endocytic pathway. Its regulatory role ties closely with the ARF6 protein another small GTPase that influences endocytosis and actin reorganization. Through its interaction in these pathways ARF GAP 2 assists in the coordination of membrane compartmentalization and dynamic changes.
ARF GAP 2 has associations with neurological and cardiovascular conditions. Its role in regulating actin structures and vesicular trafficking implicates it in disease pathways connected to protein mistrafficking and cellular dysfunction. In Alzheimer’s disease interactions with Tau protein point to a possible contribution in neurodegeneration. Similarly in cardiovascular disease its relationship with ARF6 suggests involvement in endothelial dysfunction and aortic aneurysm formation.