Abcam, ab134134, Anti-ABL1 + ABL2 antibody [EPR1222(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ABL2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1222(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABL1 and ABL2 also known as c-Abl and Arg are non-receptor tyrosine kinases that play significant roles in cellular processes. These proteins have molecular masses of approximately 120 and 140 kilodaltons respectively. ABL1 and ABL2 share structural similarities with other kinases but have unique regions that allow them to participate in specific cellular tasks. They are widely expressed in various tissues including hematopoietic cells indicating their involvement in diverse physiological functions.
Biological function summary
ABL1 and ABL2 contribute to essential cellular processes such as cell differentiation cell division adhesion and stress response. These kinases do not typically form complexes but they can interact with other proteins to fulfill their roles. They modulate cytoskeletal dynamics impacting cellular architecture and motility and are important in regulating responses to DNA damage. Their activity depends on phosphorylation events which can both activate and inhibit their functions.
Pathways
ABL1 and ABL2 participate in the regulation of the MAPK and p53 pathways. They influence cellular responses to growth factors and stress. In the MAPK pathway ABL1 and ABL2 interact with proteins like Grb2 and SOS mediating signal transduction that impacts cellular proliferation. Their roles in the p53 pathway involve modulating apoptosis and cell cycle arrest important for maintaining genome integrity.
ABL1 is strongly associated with chronic myeloid leukemia (CML) particularly through its fusion with the BCR gene to form the BCR-ABL oncogene. This oncogene results in unregulated tyrosine kinase activity that leads to excessive cellular proliferation. ABL2 has connections to solid tumors and neuropathies though its role is less defined than ABL1. Both kinases emerge as potential targets for therapeutic interventions in cancers and disorders related to dysregulated kinase activity.