Abcam, ab134269, Anti-CACNA1G antibody [N178A/9]

Size: 100µg
Mouse Monoclonal Voltage-dependent T-type calcium channel subunit alpha-1G antibody. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 5 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N178A/9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab134269 does not cross-react with CACNA1H (Cav3.2).

Product details:
The clone number has been updated from S178A-9 to N178A/9, both clone numbers name the same antibody clone.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein CACNA1G also known as Cav3.1 is a T-type voltage-gated calcium channel. This channel has a mass of approximately 251 kDa. CACNA1G primarily functions in the passage of calcium ions across the cell membrane. It is expressed in various tissues with high levels in the brain heart and kidney. Its presence in neurons and cardiac cells contributes to the low-voltage activated calcium currents important for cellular excitability.
Biological function summary
CACNA1G conducts calcium currents and influences cellular activities like neuronal firing and pacemaker potentials. CACNA1G forms part of a larger complex involving other voltage-gated calcium channels which work together to regulate calcium signaling. It modulates processes such as neurotransmitter release muscle contraction and gene expression. By controlling calcium ion influx it plays a role in maintaining intracellular calcium levels important for cellular function.
Pathways
CACNA1G is involved in calcium signaling and cardiac action potential pathways. These pathways are important for the regulation of heart rhythm and neuronal activities. CACNA1G interacts with proteins such as calmodulin influencing calcium channel function and subsequent signaling events. It also connects to the broader pathway of excitation-contraction coupling in cardiac tissues and neurotransmission in neurons.
CACNA1G has been linked to epilepsy and heart arrhythmias. Mutations in CACNA1G can alter calcium channel function affecting neuronal excitability and potentially leading to epileptic seizures. In cardiac tissues abnormalities in CACNA1G function can disrupt the cardiac action potential contributing to arrhythmias. Researchers have noted connections between CACNA1G and other ion channel proteins influencing our understanding of these disease mechanisms.