Abcam, ab134308, Anti-NMDAR1 antibody [N308/48] - Neuronal Marker

Size: 100µg
Anti-NMDAR1 antibody [N308/48] - Neuronal Marker (ab134308) is a mouse monoclonal antibody detecting NMDAR1 in Western Blot, Flow Cytometry, ICC/IF . Suitable for Human, Mouse, Rat . - Over 10 publications
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N308/48,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat, Human, Mouse,
Applications:ICC/IF, Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Fusion protein corresponding to aa 1-400 of Grin1, fused to Grin1. The exact immunogen used to generate this antibody is proprietary information.P35439

Product details:
What is this antibody validated in?
Anti-NMDAR1 antibody [N308/48] - Neuronal Marker (ab134308) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of NMDAR1?
Anti-NMDAR1 [N308/48] - Neuronal Marker (ab134308) specifically detects a band for NMDAR1 (UniProt: P35439) at a molecular weight of 105kDa.
Trusted by the scientific community
Anti-NMDAR1 [N308/48] - Neuronal Marker (ab134308) was first used in a scientific publication in 2012 and has been cited over 10 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NMDAR1 also known as GluN1 is a subunit of the NMDA receptor a type of ion channel protein found in the brain. This receptor weighs around 120 kDa and plays an important role in synaptic transmission and plasticity. NMDAR1 operates as part of a receptor complex that allows for calcium influx when activated. It shows high expression throughout the central nervous system primarily in neurons across the cortex and hippocampus. The receptor's function is important to certain calcium-dependent processes in the brain.
Biological function summary
NMDA receptors including the NMDAR1 subunit serve essential functions in synaptic plasticity and memory processes. As part of the receptor complex NMDAR1 contributes to the control of synaptic strength. It requires co-activation by glutamate and glycine or D-serine linking its function to excitatory neurotransmission. The receptor's capacity to modulate synaptic connections forms the basis of learning and long-term memory.
Pathways
NMDAR1 plays a critical role in the glutamatergic pathway influencing synaptic plasticity and memory function. It interacts with other proteins like PSD-95 within the postsynaptic density. NMDAR1 is also involved in the calcium signaling pathway due to its ability to facilitate calcium entry into neurons upon synaptic activity. This positions the receptor as an important modulator in pathways that control neuronal communication and plasticity.
NMDA receptor dysfunction including the NMDAR1 subunit links to neurodegenerative diseases such as Alzheimer's. The alterations in NMDAR1 function can lead to excitotoxicity contributing to neuronal damage. NMDAR1 also associates with schizophrenia where altered glutamatergic transmission has been observed. Here abnormalities in proteins like the synaptic scaffolding protein PSD-95 have also been noted to relate to NMDAR1 dysfunction in the pathophysiology of these disorders.