Abcam, ab134546, Recombinant Human SH3BGRL3 protein

Size: 100µg
Recombinant Human SH3BGRL3 protein is a Human Full Length protein, in the 1 to 93 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9H299,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH3BGRL3 also known as SH3 domain binding glutamic acid-rich protein-like 3 is a small protein with a molecular mass of approximately 17 kDa. This protein is expressed in a variety of tissues including the liver heart and muscle. It contains an SH3 binding domain known to interact with SH3 domains of other proteins providing a regulatory mechanism in cell signaling. The protein is also highly expressed in certain tumor cells indicating its potential role in cellular transformation and cancer.
Biological function summary
The protein is involved in several cellular processes including signal transduction and cytoskeleton organization. SH3BGRL3 functions as part of a protein complex that modulates interactions between signaling molecules and cytoskeletal components. It plays an important role in maintaining cellular architecture and facilitating cell communication by interacting with other proteins inside the cell. This interaction can affect cell structure and growth.
Pathways
This protein participates in signal transduction and cytoskeletal dynamics pathways. It interacts with proteins such as Src which is involved in various signaling cascades. SH3BGRL3's connection to the Src signaling pathway is significant as it can modulate processes like cell proliferation and differentiation. The protein is also linked with actin cytoskeleton pathways further highlighting its role in maintaining cell structure integrity.
Research connects SH3BGRL3 to cancer and cardiovascular diseases. Its expression levels in tumor cells are linked to cancer progression potentially serving as a biomarker for tumor development. In cardiovascular disorders alterations in SH3BGRL3 can affect heart muscle function possibly influencing disease outcomes. The protein has associations with Src in both cancer and heart diseases suggesting a broader role in disease mechanisms through these pathways.