Abcam, ab134951, Anti-Zic1 antibody [EPR7291(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZIC1 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7291(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Zic1 also known as Zinc Finger Protein of the Cerebellum 1 is a transcription factor with a molecular mass of approximately 55 kDa. It belongs to the ZIC family of proteins which contains a zinc finger motif that aids in DNA binding. Zic1 expresses mainly in the developing cerebellum and other parts of the brain during embryogenesis. It plays an important role in the transcriptional regulation of genes involved in neural development.
Biological function summary
Transcription factors like Zic1 regulate gene expression for cellular differentiation and proliferation. Zic1 does not act alone but interacts within a protein complex to modulate gene expression patterns critical for proper brain formation. Its activity affects processes such as neuronal precursor specification and cranial neural crest development. These functions highlight Zic1's central role in nervous system development and enhancement.
Pathways
Transcriptional regulation features Zic1 in specific routes related to neural development including the Hedgehog and Wnt signaling pathways. In the Hedgehog pathway Zic1 regulates the expression of genes linked to pattern formation in neural tissues. Zic1 also interacts with other proteins such as GLI transcription factors within the Wnt signaling pathway influencing cell fate decisions.
Mutations or dysregulations of Zic1 associate with several neurological conditions such as Dandy-Walker syndrome and medulloblastoma. Abnormal Zic1 expression can disrupt normal cerebellar development contributing to these disorders. Additionally it interacts with proteins like Pax3 which is involved in neural tube defects linking Zic1 to broader developmental diseases.