Abcam, ab134952, Anti-ACBD3 antibody [EPR8623]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ACBD3 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8623,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACBD3 also known by its alternate name GCP60 is a protein weighing approximately 60 kDa. This protein expresses in multiple tissues with significant presence in the Golgi apparatus where it plays a major role in maintaining Golgi structure and trafficking. ACBD3 helps anchor various proteins to the Golgi membranes facilitating essential cellular processes. It operates as a scaffold protein interacting with other proteins to regulate cellular localization and transport activities efficiently.
Biological function summary
ACBD3 plays a critical part in various cellular functions beyond just Golgi apparatus maintenance. It closely associates with other proteins to form part of larger functional networks such as the polypeptide N-acetylgalactosaminyltransferase enzyme complex. Through these interactions ACBD3 influences processes like lipid metabolism protein glycosylation and sterol biosynthesis. Its action is tied to the coordination of intracellular signaling and organization making it an important player in diverse cellular mechanisms.
Pathways
ACBD3 contributes significantly to the Golgi-ER transport pathway. This pathway is essential for protein sorting and trafficking impacting how proteins are directed and modified. ACBD3 interacts with proteins like PI4KB and GOLGA7 important for phosphoinositide signaling which regulates membrane trafficking and signaling at the Golgi. These pathways connect to broader cellular networks and ensure proper function and organization within the cell.
ACBD3 has links with several conditions highlighting its functional significance. Altered ACBD3 activity associates with neurodegenerative diseases and cancers. It interacts with proteins such as Coxsackievirus and Adenovirus Receptor (CAR) in viral infections illustrating its role in disease mechanisms. These interactions highlight the potential of ACBD3 as a target for therapeutic intervention or a biomarker in disease diagnosis and progression.