Abcam, ab136542, Anti-HuR / ELAVL1 antibody [4C8]

Size: 100µg
Mouse Monoclonal HuR / ELAVL1 antibody. Carrier free. Suitable for Flow Cyt, WB, EMSA and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human ELAVL1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4C8,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Human,
Applications:EMSA, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELAVL1. The exact immunogen used to generate this antibody is proprietary information.Q15717,
Specificity:ab136542 was specifically selected because of it's abiity to supershift HuR/mRNA ribonucleoprotein complexes. ab136542 does not react with HuD, HuC, or Hel-N1.

Properties and Storage Information:
Form-Liquid, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HuR also known as ELAVL1 is a protein that binds RNA in cells. It weighs about 36 kDa and is found in the nucleus and cytoplasm. Its name HuR comes from its similarity to human antigen R. Researchers often call it the HuR protein or ELAVL1 protein. This protein helps stabilize certain mRNA molecules by binding to AU-rich elements (AREs) in their 3' untranslated regions. Its binding affects mRNA decay rates and therefore influences protein synthesis.
Biological function summary
HuR influences cell growth differentiation and stress responses. It does not work alone; it often forms part of larger ribonucleoprotein complexes. By stabilizing mRNAs HuR ensures the continuous production of proteins necessary for cell survival and adaptation to stressors. This regulatory role highlights its involvement in many cellular processes making it a focus for study in relation to cellular homeostasis.
Pathways
HuR is part of the mRNA surveillance pathway and the response to cellular stress. HuR modulates gene expression by interacting with proteins involved in transcription and translation regulation. It frequently partners with proteins like TTP (tristetraprolin) that also bind to AREs affecting mRNA stability and translation processes. Such interactions extend HuR's influence across pathways related to gene expression regulation and response to stress.
Researchers associate HuR with cancer and neurodegenerative diseases. In cancer HuR stabilizes mRNAs of many oncogenes aiding tumor growth and progression. It may interact with proteins like p53 affecting tumor suppressor pathways. For neurodegenerative diseases HuR's role in mRNA stability can influence neural health connected to proteins like TDP-43 in conditions such as Alzheimer's and ALS. Understanding HuR's function offers insights into potential therapeutic targets for these diseases.