Abcam, ab1366, Anti-PPP2R5B antibody

Size: 100µg
Goat Polyclonal PPP2R5B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform aa 450 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15173

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPP2R5B also known as Protein Phosphatase 2 Regulatory Subunit B56 Beta is a regulatory subunit of protein phosphatase 2A (PP2A). It has a molecular mass of approximately 56 kDa. This protein is expressed in various tissues with higher expression in the brain heart and skeletal muscle. Its mechanical function involves modulating PP2A activity by directing the phosphatase to specific substrates which impacts diverse cellular processes.
Biological function summary
The subunit modulates several key processes including cell growth division and apoptosis. It serves as part of the PP2A holoenzyme complex a major Ser/Thr phosphatase. This complex influences many signaling pathways by dephosphorylating target proteins. Through interactions with other B subunits the specific regulatory effects of B56 beta become fine-tuned providing this subunit with precise control over cellular outcomes.
Pathways
PPP2R5B plays a role in essential signaling cascades such as the MAPK/ERK and PI3K/AKT pathways. These pathways regulate diverse cell functions including proliferation and survival. PPP2R5B coordinates with other proteins like Bcl-2 and p53 in these pathways to regulate apoptosis and cell cycle progression. Its ability to influence these pathways places it at a pivotal point in the signal transduction network.
Alterations in PPP2R5B function have links to cancer development and Alzheimer’s disease. In cancer its relationship with p53 suggests a role in tumor suppression as PPP2R5B can affect p53 stability. In neurodegenerative contexts such as Alzheimer’s the improper regulation of phosphorylation sites could contribute to pathogenesis again implicating pathways like PI3K/AKT. Identifying PPP2R5B interactions is important for understanding disease mechanisms.