Abcam, ab137060, Anti-Amino-terminal enhancer of split/AES antibody [EPR8385]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Amino-terminal enhancer of split/AES antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8385,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Amino-terminal enhancer of split commonly known as AES is a protein with a molecular mass of approximately 22 kDa. It functions as a transcriptional repressor and is involved in controlling gene expression by interacting with DNA. AES is expressed in various tissues including the brain heart and liver indicating its broad role in different biological processes. Its ability to inhibit specific gene expression highlights its involvement in intricate regulatory mechanisms. Researchers also recognize the protein by other names such as enhancer protein and protein enhancer.
Biological function summary
AES interacts with corepressor proteins to form a complex that modulates transcriptional activity. This complex involvement is critical for developmental processes and cell differentiation affecting how cells acquire specialized functions. Through these interactions AES influences the activities of target genes that are essential for organismal development. The presence of AES in significant developmental pathways highlights its regulatory function in cellular mechanisms.
Pathways
AES plays an important role in the Notch signaling and Wnt signaling pathways both integral to cellular differentiation and proliferation. AES specifically interacts with components of these pathways acting to modulate their signaling outcomes. In the Notch signaling pathway AES functions by repressing gene expression therefore maintaining proper cellular balance. Similarly within the Wnt signaling pathway AES interacts with other pathway proteins such as TCF7L2 to adjust gene transcription ensuring normal cellular development and proliferation.
AES has connections to certain types of cancer and neurodevelopmental disorders. Aberrant expression or mutation of AES can lead to disruptions in normal signaling contributing to pathological conditions. In cancer the dysregulation of the Notch signaling pathway where AES plays an important regulatory role is often associated with tumorigenesis. Additionally AES interactions with other proteins like TCF7L2 in Wnt signaling pathways may be implicated in colorectal cancer progression. In neurodevelopmental disorders alterations in the AES function can affect brain development potentially leading to conditions like autism spectrum disorders.