Abcam, ab137067, Anti-PSMB4 antibody [EPR9396]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PSMB4 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9396,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMB4 also known as proteasome subunit beta type-4 is a critical component of the 20S proteasome complex involved in protein degradation. Its molecular mass is approximately 29 kDa. PSMB4 expression occurs widely including in the cytoplasm and nucleus of eukaryotic cells. It plays an important role in regulating protein turnover by participating in the breakdown of ubiquitinated proteins essential for maintaining cellular protein homeostasis.
Biological function summary
The 20S proteasome where PSMB4 belongs acts as the proteolytic core of the 26S proteasome complex. This complex degrades unwanted or damaged proteins thereby regulating various cellular processes such as the cell cycle apoptosis and DNA repair. PSMB4's activity ensures the removal of potentially toxic proteins which is important for cell function and survival.
Pathways
PSMB4 is involved in key pathways such as the ubiquitin-proteasome pathway and antigen processing. These pathways regulate protein metabolism and assist in immune surveillance by presenting endogenous antigens through MHC class I molecules. PSMB4 interacts closely with other proteasome subunits like PSMB5 and PSMB6 which coordinate to cleave peptide bonds in substrate proteins effectively.
Mutations or dysregulation of PSMB4 link to multiple myeloma and neurodegenerative diseases. In multiple myeloma changes in PSMB4 may affect proteasome inhibitor effectiveness while in neurodegenerative disorders impaired protein degradation can lead to protein aggregation. PSMB4 has potential interactions with proteins such as ubiquitin and PSMC3 which further influence disease progression.