Abcam, ab137099, Anti-Placental lactogen antibody [EPR8265]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CSH2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8265,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Placental lactogen also known as chorionic somatomammotropin hormone is a glycoprotein hormone with a molecular mass of approximately 22 kDa. The hormone is primarily expressed in the syncytiotrophoblasts of the placenta during pregnancy. It shares structural similarities with other hormones like growth hormone and prolactin due to its polypeptide nature. Placental lactogen influences various physiological processes related to maternal and fetal development.
Biological function summary
Placental lactogen functions to modulate maternal metabolism to support fetal growth and development. It promotes changes in the maternal glucose metabolism ensuring an adequate energy supply to the fetus. This protein also stimulates mammary gland development preparing the mother for lactation. It does not form part of a larger protein complex acting independently in the biological processes it regulates.
Pathways
Researchers have found that placental lactogen plays a role in both the insulin-like growth factor (IGF) pathway and the JAK-STAT signaling pathway. It interacts with the IGF pathway to enhance nutrient uptake and fetal growth. Additionally its role in the JAK-STAT pathway ties it to immune modulation and cell proliferation. Placental lactogen is related to proteins such as the growth hormone and prolactin within these pathways due to their shared structural properties and similar mechanisms of action.
Studies have linked abnormal levels of placental lactogen to gestational diabetes mellitus and pre-eclampsia. Gestational diabetes arises when placental lactogen induces higher insulin resistance impacting maternal glucose regulation. Pre-eclampsia may involve imbalance in placental lactogen expression affecting placental vascular function. Researchers have noted interactions with proteins like leptin and insulin as these relate to glucose metabolism and vascular changes in pregnancy.