Abcam, ab137250, Anti-RRP41 antibody

Size: 100µg
Rabbit Polyclonal RRP41 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human EXOSC4 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EXOSC4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9NPD3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab137250 was affinity purified using an epitope specific to RRP41 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RRP41 also known as EXOSC4 is a subunit of the RNA exosome complex. It is involved in the degradation and processing of RNA. With molecular mass approximately 27 kDa RRP41 partakes in catalytic core activities within the exosome. Scientists have identified its presence mainly in the nucleus and cytoplasm highlighting its broad cellular expression.
Biological function summary
RRP41 participates in RNA metabolism by aiding in the degradation of various RNA species. It is a component of the exosome complex which consists of several other subunits working together to process RNA. This complex is vital in maintaining RNA homeostasis allowing cells to regulate gene expression effectively. RRP41's role in the exosome ensures proper processing of ribosomal RNA (rRNA) messenger RNA (mRNA) and other RNA molecules.
Pathways
RRP41 functions within the RNA surveillance pathway. This pathway helps identify and eliminate defective RNA therefore ensuring RNA quality control within the cell. Additionally it interacts with other proteins such as RRP42 and RRP43 which are also part of the exosome complex. The interaction between these proteins is important in regulating RNA degradation and processing functions safeguarding the precision of cellular activities.
RRP41 displays connections to autoimmune diseases such as systemic lupus erythematosus (SLE). Misregulation of exosome functions including RRP41 might contribute to the improper clearance of RNA leading to disease development. Furthermore interactions with proteins like RRP45 which also play roles in RNA processing suggest RRP41 involvement in the pathophysiology of certain RNA-related disorders.