Abcam, ab137390, Anti-PACSIN1 antibody

Size: 100µL
Rabbit Polyclonal PACSIN1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PACSIN1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PACSIN1.Q9BY11

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PACSIN1 also known as Syndapin I is a protein that plays a role in membrane trafficking and cytoskeleton organization. It has an alternative name Syndapin I and its molecular mass is approximately 50 kDa. This protein is expressed in the brain particularly in the neuronal tissues where it associates with membranes and interacts with other proteins to regulate endocytosis. Through its F-BAR domain PACSIN1 senses membrane curvature and participates in membrane tubulation processes.
Biological function summary
PACSIN1 contributes to neuronal function by being a component of endocytic and cytoskeletal complexes. It interacts with dynamin and synaptojanin-1 facilitating the assembly of these complexes upon curved membranes. This interaction promotes synaptic vesicle recycling which is critical for efficient neurotransmitter release and synaptic transmission. PACSIN1 is an important part of the vesicle trafficking machinery in neurons directly affecting the dynamics of synapses and overall neuronal communication.
Pathways
PACSIN1 is integrated into the synaptic vesicle cycle and the actin cytoskeleton remodeling pathway. It collaborates with proteins like dynamin I and actin to regulate endocytosis and membrane shaping during synaptic vesicle recycling. These pathways underpin the synaptic vesicle cycle's efficiency and the maintenance of the actin cytoskeleton structure. PACSIN1's interaction with dynamin I demonstrates its significant role in modulating endocytosis speed and efficacy.
PACSIN1 has associations with neural complications like epilepsy and Parkinson's disease. It interacts with synaptic proteins such as synaptojanin-1 whose dysregulation can lead to synaptic dysfunction contributing to these disorders. Impaired PACSIN1 function could disrupt normal synaptic activity leading to neurodegenerative symptoms observed in these diseases. Understanding its role can provide insights into potential therapeutic targets for neurological conditions.