Abcam, ab137455, Anti-ERAB antibody

Size: 100µL
Rabbit Polyclonal ERAB antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HSD17B10 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HSD17B10 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q99714

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ERAB also known as 17-beta-hydroxysteroid dehydrogenase type 10 (HSD10) or 3-hydroxyacyl-CoA dehydrogenase type II is a multifunctional mitochondrial enzyme. It has a molecular mass of approximately 27 kDa. This enzyme is expressed in various tissues with high expression in the liver kidney heart and brain. ERAB plays a role in several metabolic processes thanks to its ability to catalyze reactions involving the oxidation of hydroxyacyl-CoA to ketoacyl-CoA derivatives alongside other substrates like steroids.
Biological function summary
The function of this enzyme extends beyond its metabolic activities. ERAB is part of the mitochondrial enzyme complex responsible for fatty acid oxidation and energy production. This places it centrally in cellular energy homeostasis. Additionally ERAB participates in the metabolism of neurosteroids which impacts brain function. Through its interactions ERAB influences signaling pathways by modulating local steroid concentrations in the nervous system affecting cellular communication and response.
Pathways
ERAB associates with key biochemical pathways including the beta-oxidation of fatty acids and the steroid hormone metabolism pathway. It interacts with acetyl-CoA acyltransferase 2 (ACAA2) within these metabolic pathways facilitating the conversion of substrates vital for energy production and steroid synthesis. This involvement underpins the enzyme’s significance in maintaining metabolic equilibrium through its catalytic activities on essential biological molecules.
ERAB has links to Alzheimer's disease and rare mitochondrial disorders. Studies show that ERAB binds amyloid-beta peptides which accumulate in the brains of Alzheimer's disease patients. This interaction suggests ERAB's potential contribution to the pathogenesis of the disease. Additionally mutations affecting ERAB lead to HSD10 mitochondrial disease a disorder characterized by metabolic and neurological defects. One of the proteins that interacts with ERAB in the context of disease is amyloid precursor protein (APP) which further implicates ERAB in Alzheimer's disease through pathological pathways.