Abcam, ab137600, Anti-RGL2 antibody

Size: 50µL
Rabbit Polyclonal RGL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGL2 aa 100-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RGL2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information.O15211

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RGL2 also known as Ral Guanine Nucleotide Dissociation Stimulator-Like 2 is a protein that functions importantly in the regulation of small GTPases. It has a mass of approximately 109 kDa. RGL2 is expressed in various tissues but high levels are often present in the nervous tissue and the endocrine system. This expression pattern suggests its involvement in neuronal signaling and hormonal regulation.
Biological function summary
Ral Guanine Nucleotide Dissociation Stimulator-Like 2 acts as a guanine nucleotide exchange factor (GEF) which activates Ral GTPases by facilitating the exchange of GDP for GTP. The protein is a member of the RAS subfamily GEFs and contributes greatly to the formation of signaling complexes that affect multiple cellular processes. RGL2 interacts with other proteins to modulate cell growth cytoskeletal organization and vesicle trafficking.
Pathways
RGL2 plays a role in the MAPK/ERK signaling pathway and the PI3K/Akt pathway. These pathways are critical for cell proliferation and survival. It works closely with RalA and RalB proteins acting as a mediator in transmitting signals from receptor tyrosine kinases. Through this interaction RGL2 contributes to the regulation of cell cycle progression and apoptosis.
RGL2 has associations with cancer and neurodegenerative diseases. In some cancers upregulation of RGL2 leads to uncontrolled cellular proliferation where the protein interacts with other members of the Ras signaling pathway like c-Raf. Furthermore RGL2's role in neurodegenerative diseases is revealed by its impact on neuronal signaling potentially influencing conditions such as Alzheimer's disease through dysfunction in vesicular trafficking and synaptic plasticity.