Abcam, ab138005, Anti-JAK1 (phospho Y1034 + Y1035) antibody [EPR1899(2)]

Size: 20µL / 100µL / 1mL
Anti-JAK1 (phospho Y1034 + Y1035) antibody [EPR1899(2)] (ab138005) is a rabbit monoclonal antibody detecting JAK1 in Western Blot, IHC-P, ELISA, Dot Blot . Suitable for Human . - Biophysical QC for unrivalled batch-batch consistency - Over 40 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1899(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ELISA, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:According to our ELISA result, this antibody preferentially recognizes JAK1 with phospho Y1035, but also recognizes JAK1 with phospho Y1034 if high amount peptides were coated.

Product details:
What is this antibody validated in?
Anti-JAK1 (phospho Y1034 + Y1035) antibody [EPR1899(2)] (ab138005) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), ELISA, Dot Blot in Human samples.
What is the molecular weight of JAK1?
Anti-JAK1 (phospho Y1034 + Y1035) [EPR1899(2)] (ab138005) specifically detects a band for JAK1 (UniProt: P23458) at a molecular weight of 133kDa.
Trusted by the scientific community
Anti-JAK1 (phospho Y1034 + Y1035) [EPR1899(2)] (ab138005) was first used in a scientific publication in 2012 and has been cited over 40 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR1899(2)] also available for your convenience: ab138005, Carrier free -
ab203784
, HRP -
ab215338
, Alexa Fluor® 488 -
ab310950
, Alexa Fluor® 647 -
ab311068
, Alexa Fluor® 568 -
ab312925
, Alexa Fluor® 555 -
ab313138
Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.21% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JAK1 also known as Janus Kinase 1 plays an essential role in transmitting signals within cells. It is a tyrosine kinase enzyme with a molecular weight of approximately 130 kDa. JAK1 is expressed broadly in various tissues and is involved in cytokine receptor signaling. The kinase activity of JAK1 gets activated upon cytokine binding to its respective receptor which leads to phosphorylation events and downstream signaling cascades.
Biological function summary
This enzyme participates significantly in the immune response and hematopoiesis by being part of the JAK-STAT signaling pathway complex. When activated JAK1 phosphorylates specific tyrosine residues on the receptor creating docking sites for STAT proteins which then get phosphorylated by JAK1. This phosphorylation allows STAT proteins to dimerize and translocate to the nucleus affecting gene expression involved in growth survival and differentiation processes.
Pathways
JAK1 is importantly engaged in the JAK-STAT pathway and the Interferon signaling pathway. Within these pathways JAK1 collaborates closely with other proteins like JAK2 TYK2 and STAT proteins. It acts as a mediator of the cellular response to a variety of cytokines and growth factors playing a role in the regulation of immune responses and cell proliferation.
Dysregulation of JAK1 associates with autoimmune diseases like rheumatoid arthritis and certain cancers. JAK1 inhibitors have been developed as therapeutic agents for these conditions targeting its kinase activity to modulate aberrant signaling. The interaction between JAK1 and other kinases such as JAK2 and transcription factors like STATs highlights its importance in disease mechanisms providing a target for drugs to manage inflammatory and malignant disorders.