Abcam, ab138707, Anti-Major latex allergen Hev b 5 antibody [5-11.6]

Size: 100µg
Mouse Monoclonal Major latex allergen Hev b 5 antibody. Suitable for ELISA and reacts with Hevea brasiliensis samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Hevea brasiliensis ALL5_HEVBR.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:5-11.6,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Hevea brasiliensis,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Hevea brasiliensis ALL5_HEVBR. The exact immunogen used to generate this antibody is proprietary information.Q39967,
Specificity:ab138707 reacts with both recombinant and native Major latex allergen Hev b 5.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Major latex allergen Hev b 5 also known as the acidic protein 5 is a 16 kDa protein found in the latex of Hevea brasiliensis the rubber tree. This protein functions mechanistically by acting as a prohevein which serves structural and binding roles essential for latex production. Hev b 5 exists mainly within the cytosolic compartments of rubber tree laticifers the specialized cells responsible for the synthesis and storage of latex. Its presence is integral to the mechanical stability and processing of latex particles.
Biological function summary
The major latex allergen Hev b 5 contributes to the natural defense mechanism of the rubber tree against pathogens. While not precisely part of a large multiprotein complex its structural characteristics facilitate aggregation tendencies with other latex proteins strengthening the physical properties of natural rubber. This aggregation also serves connections with other allergenic proteins increasing their surface availability potentially enhancing allergenicity in susceptible individuals.
Pathways
Proteins derived from Hev b 5 participate in pathways related to the plant's intrinsic immune defense. One key pathway involves its role in latex coagulation where it interacts with hevein-like proteins enhancing the tree's response to mechanical injury. Additionally Hev b 5 links to the biosynthesis and modification pathway of natural rubber sharing proteomic networks with proteins like Hev b 1 and Hev b 3 which mediate the cross-linking process essential for latex formation.
Major latex allergen Hev b 5 plays a significant role in latex allergy a prevalent concern for individuals with occupational exposure. This allergen similar to related proteins like Hev b 1 and Hev b 6 triggers IgE-mediated allergic responses leading to disorders such as contact dermatitis and respiratory complications. Additionally Hev b 5's structural similarities to other plant-derived allergens can invoke cross-reactivity heightening allergic conditions in sensitized patients.