Abcam, ab139211, Recombinant Human TBP like protein TLP

Size: 50µg
Recombinant Human TBP like protein TLP is a Human Full Length protein, in the 1 to 186 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P62380,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBP-like protein TLP also known as TBPL1 is a member of the TATA-binding protein family and has a mass of approximately 31 kDa. TLP is expressed in various tissues throughout the body with notable expression in testis liver and muscle. It functions by binding to the TATA box of DNA a critical component of gene promoters and participates in forming the transcription pre-initiation complex required for RNA polymerase II-mediated transcription.
Biological function summary
TBP-like protein TLP plays a role in the regulation of transcription by serving as part of a multiprotein complex that impacts gene expression. It interacts with other transcription factors to modulate the initiation of transcription of specific genes. TLP can bind distinct promoter sequences allowing for regulatory flexibility in gene expression aiding in developmental and differentiation processes across different tissues.
Pathways
TBP-like protein TLP integrates into transcriptional regulation pathways particularly in the assembly of the transcription pre-initiation complex. This protein collaborates with other proteins like TBP and TFIIA in the transcription machinery. It also participates in chromatin remodeling pathways facilitating changes in DNA accessibility necessary for transcriptional regulation. TLP's ability to engage with these pathways highlights its role in genetic regulatory networks.
TBP-like protein TLP has connections to particular conditions such as testicular germ cell tumors and specific forms of liver disease. Its interaction with TBP is significant as alterations in these transcriptional regulators can impact gene expression patterns linked to tumorigenesis and liver pathology. Understanding TLP's role in these diseases could open up new therapeutic approaches by targeting its activity or interactions within affected tissues.