Abcam, ab139624, Recombinant human STK19/G11 protein

Size: 10µg
Recombinant human STK19/G11 protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE, WB, FuncS.
Key facts
Purity:>70% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:SDS-PAGE, FuncS, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab139624 was determined to be 2 nmol/min/mg.,
Accession:P49842,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Product details:
ab204856
(CREB peptide) can be utilized as a substrate for assessing kinase activity
Previously labelled as STK19.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK19 also known as G11 is a serine/threonine kinase that plays a mechanical role in phosphorylating specific protein substrates. It has an approximate molecular mass of 38 kDa. Expression of STK19 occurs in a variety of tissues with higher expression levels found in immune cells and certain areas of the brain. The kinase activity of STK19 modulates several cellular processes through phosphorylation acting as a regulatory switch for protein function.
Biological function summary
STK19 participates in signal transduction pathways by phosphorylating proteins that are involved in cell signaling and proliferation. It is part of a larger protein complex that includes scaffolding proteins which help in localizing and stabilizing STK19 within the cell. In immune cells STK19 plays a role in modulating the cellular immune response influencing both the adaptive and innate immune pathways.
Pathways
The action of STK19 is significant in the MAPK/ERK signaling pathway which is essential for cell growth and differentiation. This pathway interacts with proteins such as RAF1 and MEK1 where STK19's kinase activity is important for propagating signaling cascades that impact cellular outcomes. STK19 also interfaces with the PI3K/AKT pathway engaging in cell survival and metabolism regulation through phosphorylation events.
STK19 has been associated with autoimmune diseases and certain cancers. Aberrant expression or mutation of STK19 can contribute to immune system dysfunction linking it with proteins like STAT3 in the context of autoimmunity. Additionally STK19 mutations or dysregulation may influence oncogenic processes interacting with other key proteins such as p53 which is known to regulate cell cycle and tumorigenesis. Scientists continue to study STK19 to better understand its full role and potential as a therapeutic target in these disorders.