Abcam, ab139715, Anti-Pannexin 1 antibody

Size: 100µg
Rabbit Polyclonal Pannexin 1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human PANX1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PANX1. The exact immunogen used to generate this antibody is proprietary information.Q96RD7,
Specificity:Two transcript variants encoding different isoforms have been found for this gene.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pannexin 1 also known as PANX1 is a membrane channel protein with a mass of approximately 48 kDa. This protein functions as an important part of the cellular communication system by forming channels that facilitate the release of ATP and other signaling molecules from the cytoplasm to the extracellular space. It is widely expressed across various tissues including the central nervous system skin and muscles. Pannexin-1 is often found on the cell surface where it operates in coordination with other cellular components to regulate intercellular interactions and signaling networks.
Biological function summary
Pannexin 1 plays a significant role in various physiological processes such as inflammation apoptosis and synaptic plasticity. It forms part of large multiprotein complexes that can include connexins and other ion channels. Through these complexes pannexin 1 helps mediate the flow of ions and small molecules across the cell membrane influencing cellular responses and communication. The ATP release mediated by pannexin-1 channels is particularly involved in activating purinergic receptors on neighboring cells contributing to diverse cellular responses.
Pathways
Pannexin 1 participates actively in the purinergic signaling pathway where it plays a role in ATP mediated communication between cells. This protein also integrates into the inflammasome pathway impacting inflammation and immune responses. Within these pathways pannexin-1 interacts with proteins such as P2X7 receptors which are essential for the activation of specific signaling cascades linked to these biological processes. The interaction with other channels like connexins enhances its regulatory role in physiological functions.
Pannexin 1 has been implicated in the pathophysiology of conditions such as epilepsy and skin disorders. Its ability to control ATP release and consequently influence neuron excitability relates significantly to the onset and progression of epilepsy. PANX1 also interacts with cytokines in skin cells where dysregulation can contribute to inflammatory skin conditions. Additionally alterations in pannexin-1 function and expression have connections to changes in P2X7 receptor activities linking it to both neurological and dermatological disease pathways.