Abcam, ab140079, Anti-EGFL6 antibody

Size: 100µg
Rabbit Polyclonal EGFL6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EGFL6 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EGFL6 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q8IUX8

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EGFL6 also known as Epidermal Growth Factor-Like Protein 6 or MAEG is a secreted protein that plays a role in the regulation of cell growth. It belongs to the epidermal growth factor (EGF) repeat superfamily and has an approximate mass of 70 kDa. EGFL6 is expressed in various tissues with higher expression noted in fetal tissues particularly the lung and kidney as well as in certain adult tissues like the ovary.
Biological function summary
This protein influences cell proliferation and differentiation. EGFL6 is not a part of a larger protein complex but functions through its interactions with other cellular components. Its activity affects cell behavior which is especially noted during development and tissue regeneration processes. EGFL6 modulates the extracellular environment through binding to receptor tyrosine kinases mediating signaling that promotes cellular motility and survival.
Pathways
EGFL6 integrates into significant pathways such as the PI3K/AKT and MAPK signaling pathways. Through these pathways it maintains cellular processes related to growth and survival by interacting with proteins like AKT1 and MAPK1. These signaling cascades are fundamental in mediating responses to growth factors and adjusting cell fate decisions.
Aberrant expression of EGFL6 associates with conditions such as cancer specifically ovarian cancer and melanoma. In these contexts EGFL6 interplays with proteins like VEGF contributing to tumor growth and angiogenesis. Its role in disease suggests potential as a therapeutic target for interventions designed to modulate cancer progression.