Abcam, ab140115, Anti-PNKD antibody

Size: 100µg
Rabbit Polyclonal PNKD antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PNKD aa 150-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PNKD aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q8N490

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PNKD also known as myofibrillogenesis regulator 1 (MR-1) is a protein encoded by the PNKD gene. PNKD plays a mechanical role as it regulates myofibrillogenesis which is important for muscle development and cardiomyocyte function. The protein has a mass of approximately 46 kDa. It is expressed widely in human tissues with higher expression noted in the brain and muscle tissues. PNKD is found in both cytoplasm and the nucleus where it interacts with cellular structures essential for proper myofibril formation.
Biological function summary
PNKD is involved in muscle contraction and neurological signaling. It is a part of a larger complex that affects calcium ion binding and muscle contraction. By aiding in the assembly of sarcomeric structures PNKD ensures the stability and proper functioning of muscle fibers. In the nervous system it appears to participate in modulating synaptic activity implying a role in neural communication and plasticity.
Pathways
PNKD participates in intracellular signaling associated with muscle contraction and synaptic function. In the calcium signaling pathway it interacts with proteins such as actin and tropomyosin to facilitate muscle function. Furthermore PNKD associates with pathways affecting neurotransmitter release at synapses implicating proteins like synapsin and SNAP-25 which are important for synaptic vesicle docking and release.
PNKD mutations can lead to paroxysmal nonkinesigenic dyskinesia (PNKD) a neurological disorder characterized by involuntary movements. This condition highlights the necessity of PNKD in proper neuronal signaling. Moreover PNKD's interaction with calcium-binding proteins links it to certain types of hereditary cardiomyopathy as disruptions in calcium homeostasis can provoke cardiac muscle dysfunction. The protein's association with synaptic pathways further relates it to disorders affecting neurotransmission efficiency.