Abcam, ab140431, Anti-Parvovirus antibody [CPV1-2A1]

Size: 100µg
Mouse Monoclonal Parvovirus antibody. Suitable for ELISA, WB, IHC-P, ICC/IF and reacts with Protoparvovirus samples. Cited in 3 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CPV1-2A1,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Protoparvovirus,
Applications:IHC-P, ICC/IF, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Reacts with canine parvovirus (CPV), feline panleukopenia virus (FPLV) and mink parvovirus (Aleutian Disease). It is negative against canine adenovirus type 2, canine corona virus, canine distemper virus, canine parainfluenza virus, feline leukemia virus and feline immunideficiency virus.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Parvovirus also known as CPV1 or CPV-One is a small non-enveloped virus with a DNA genome. It measures about 5.5 kilodaltons in mass. Parvovirus is common in diverse environments and often infects rapidly dividing cells. In animals it expresses widely in tissues such as intestinal cells and bone marrow causing a range of effects depending upon the host’s species and immune status. Laboratory studies often focus on anti-parvo antibodies mono-clonal antibodies and 2a1 antibodies to further understand parvovirus behavior.
Biological function summary
Most parvoviruses target actively dividing cells using the host cell machinery for replication. In this biological process parvoviruses do not generally form a larger complex but rely on key cellular proteins for infection and propagation. The viral replication depends heavily on the host's cell cycle prompting the virus to attack cells in the S-phase where DNA replication occurs upsetting normal cellular functions. Researchers often study anti-parvo antibodies to block these interactions and prevent viral spread.
Pathways
The infection mechanism of the parvovirus involves critical pathways related to cell cycle control and apoptosis. The virus interacts with proteins like p53 which is fundamental in controlling the cell cycle and instigating apoptosis when damage is detected. Through its interaction with cellular pathways parvovirus can alter cellular responses redirecting the cellular machinery toward viral replication and protein synthesis necessary for parvovirus assembly and release.
Parvovirus infections connect frequently with canine parvovirus disease and feline panleukopenia. Both conditions result in severe gastrointestinal and immune symptoms demonstrating the virus's impact on rapidly dividing cells. During these infections the virus's interaction with fibrinogen a protein involved in inflammation and coagulation can further exacerbate clinical symptoms. Infected animals often exhibit severe leukopenia highlighting the significant distress the virus can inflict on the bone marrow and its capacity to generate white blood cells.