Abcam, ab140514, Anti-RNF25 antibody

Size: 100µg
Rabbit Polyclonal RNF25 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human E3 ubiquitin-protein ligase RNF25 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human E3 ubiquitin-protein ligase RNF25 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96BH1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab140514 was affinity purified using an epitope specific to RNF25 immobilized on a solid support., Storage buffer-pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF25 also known as RING Finger Protein 25 is a protein that acts like an E3 ubiquitin ligase. This protein has a molecular mass of approximately 40 kDa. RNF25 is involved in tagging proteins with ubiquitin a process known as ubiquitination which directs these proteins for degradation by the proteasome. You will find RNF25 expressed in a variety of human tissues with higher levels observed in the heart and skeletal muscle.
Biological function summary
The function of RNF25 impacts protein turnover and stability. It often associates with other proteins to form complexes that regulate important cellular processes such as protein homeostasis and response to stress. RNF25 contributes to the maintenance of cellular equilibrium by marking defective or unneeded proteins for removal.
Pathways
RNF25 engages in the ubiquitin-proteasome pathway which oversees the controlled degradation of proteins. This pathway is central to many cellular processes including cell cycle regulation and signal transduction. RNF25 also interacts with proteins like NF-kB playing a role in the NF-kB signaling pathway which is important in inflammatory responses.
RNF25 associations are evident in contexts like cancer and immune system disorders. Dysregulation of ubiquitination involving RNF25 can contribute to oncogenesis and affect tumor suppressor proteins such as p53. Similarly alterations in the NF-kB pathway with links to RNF25 have been implicated in autoimmune diseases indicating its significance in the regulation of immune responses.