Abcam, ab140611, Anti-HSPC150/UBE2T antibody [EPR9446]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HSPC150/UBE2T antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9446,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSPC150 also known as UBE2T is a protein involved in the ubiquitination process. It functions as a ubiquitin-conjugating enzyme essential for tagging proteins with ubiquitin marking them for degradation via the proteasome. UBE2T has a mass of approximately 22 kDa and shows expression in various tissues with higher levels found in the testis and bone marrow. It is critical in maintaining protein homeostasis by regulating the turnover of proteins within cells.
Biological function summary
HSPC150/UBE2T interacts with the Fanconi anemia (FA) complex playing a significant role within DNA repair processes. Its activity is necessary for mono-ubiquitination of the FANCD2 protein a central component of the FA pathway. Through this engagement UBE2T contributes to the repair of interstrand crosslinks in DNA therefore supporting the maintenance of genomic integrity. The protein's involvement in these processes highlights its importance in preserving proper cellular functions and preventing genomic instability.
Pathways
HSPC150/UBE2T is mainly involved in the DNA damage repair pathways particularly the Fanconi anemia pathway. In this context it collaborates with proteins like FANCL and RAD51 which are key players in homologous recombination and DNA repair. Ubiquitination of FANCD2 by UBE2T integrates into these pathways facilitating efficient DNA repair and ensuring cell survival following genotoxic stress.
Dysfunction of HSPC150/UBE2T links to cancer particularly with certain hematological malignancies. Alterations or overexpression of UBE2T can lead to defective DNA repair contributing to carcinogenesis due to accumulation of DNA damage. Furthermore associations with Fanconi anemia also illustrate its vital role given that mutations affecting UBE2T can hinder the pathway's function leading to bone marrow failure and increased cancer risk. The interaction with FANCD2 emphasizes its potential impact in conditions associated with genomic instability.