Abcam, ab140642, Anti-BAF53b antibody [EPR10100(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal BAF53b antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10100(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab140642 is likely to cross-react with the homologue ACTL6A protein, due to high homology with the immunogen sequence.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BAF53b also known as Actin-like protein 6B is a part of the SWI/SNF chromatin remodeling complex. It has a molecular mass of roughly 50 kDa. You can find BAF53b mostly in the brain with higher expression levels in the central nervous system during development. It primarily associates with the multi-subunit complexes in neurons indicating its specialized role in neural functions.
Biological function summary
BAF53b acts as an important player in regulating neuronal gene expression. It is part of the neuronal-specific BAF (nBAF) complex which contributes to the modification of chromatin structure. BAF53b has a specialization in managing chromatin accessibility during neural differentiation and synaptic development. Its interaction with other subunits in the SWI/SNF complex aids in the transcriptional activation of genes important for synaptic plasticity and memory formation.
Pathways
BAF53b plays significant roles in important cellular processes such as the Wnt signaling pathway and the transcription regulation pathway. In the Wnt pathway BAF53b collaborates with proteins such as β-catenin to influence gene transcription impacting cell division and neuronal differentiation. Its involvement in transcription regulation brings BAF53b into interaction with other remodeling proteins which together facilitate epigenetic changes needed for neuronal maturity.
Alterations in BAF53b function relate closely with neurological conditions like schizophrenia and intellectual disabilities. Abnormalities in the BAF53b-protein complexes can disrupt synaptic functions and neuronal connectivity seen in schizophrenia. BAF53b's significant association with other proteins in neural pathways points to potential roles in regulating synaptic development and maintaining neural integrity.