Abcam, ab140896, Anti-P2Y14 antibody

Size: 50µg
Rabbit Polyclonal P2Y14 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human P2RY14.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human P2RY14. The exact immunogen used to generate this antibody is proprietary information.Q15391,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P2Y14 also known as GPR105 is a G protein-coupled receptor. It has a molecular mass of approximately 40-47 kDa. P2Y14 primarily binds UDP-glucose as its ligand and plays a role in various signaling pathways. Expression of P2Y14 occurs in a variety of tissues including the immune system tissues like spleen as well as in cells such as leukocytes. It shows lower expression levels in other bodily tissues like brain and lungs.
Biological function summary
P2Y14 receptor participates in immune responses by modulating the function of various leukocytes. It does not exist as part of large multimeric complexes but interacts with the cellular machinery to influence the behavior of the immune system. Through its interaction with extracellular nucleotides and sugars P2Y14 impacts immune cell chemotaxis and cytokine release which are critical for immune regulation.
Pathways
P2Y14 receptor plays a significant role in inflammatory signaling pathways and chemotaxis. It interacts with other proteins such as P2Y12 to modulate the activation and recruitment of immune cells. P2Y14 links to key pathways such as those involving GPCR signaling impacting immune cell movement and inflammation processes.
P2Y14 has a connection to asthma and type 2 diabetes. In asthma its role in immune cell recruitment can exacerbate inflammation and contribute to symptoms. In type 2 diabetes P2Y14 influences insulin signaling potentially impacting glucose metabolism. It associates with proteins like P2X7 and P2Y12 which are involved in inflammatory processes and metabolism underlining its role in these conditions.