Abcam, ab141013, RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT)

Size: 5mg / 10mg / 50mg
MW 334.3 Da, Purity >99%. Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC 50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro . Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
Key facts
CAS number:48208-26-0,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:334.3 Da,
Molecular formula:C19H14N2O4,
PubChem:702558,
Nature:Synthetic,
Biochemical name:N-Phthalyl-L-tryptophan,
Biological description:Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.,
Canonical smiles:C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O,
Isomeric smiles:C1=CC=C2C(=C1)C(=O)N(C2=O)[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O,
InChi:InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1,
InChiKey:HPTXLHAHLXOAKV-INIZCTEOSA-N,
IUPAC Name:(2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months