Abcam, ab141125, GW 9662, PPARgamma antagonist

Size: 10mg / 50mg
MW 276.67 Da, Purity >99%. Selective PPARγ antagonist (IC 50 values are 3.3, 32, >1000 nM for PPARγ, PPARα and PPARδ respectively). Apoptotic and antimetastatic activity in vitro .
Key facts
CAS number:22978-25-2,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:276.67 Da,
Molecular formula:C13H9ClN2O3,
PubChem:644213,
Nature:Synthetic,
Solubility:Soluble in ethanol to 50 mM,
Biochemical name:2-Chloro-5-nitro-N-phenylbenzamide,
Biological description:Selective PPARγ antagonist (IC50 values are 3.3, 32, >1000 nM for PPARγ, PPARα and PPARδ respectively). Apoptotic and antimetastatic activity in vitro.,
Canonical smiles:C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl,
InChi:InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17),
InChiKey:DNTSIBUQMRRYIU-UHFFFAOYSA-N,
IUPAC Name:2-chloro-5-nitro-N-phenylbenzamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thyroid peroxidase (TPO) Estrogen Receptor (ER) Aryl hydrocarbon Receptor (AhR) Peroxisome proliferator-activated receptor gamma (PPAR gamma) GLI family zinc finger 3 (Gli3) Tyrosyl-DNA phosphodiesterase 1 (TDP1) Cytochrome P450 2C9 (CYP2C9) Androgen Receptor (AR) Retinoic Acid Receptor alpha (RAR alpha) and Pregnane X Receptor (PXR) represent a range of important biological targets. These proteins exhibit varying functions including hormonal regulation enzymatic activity and transcriptional activation. For instance TPO with a mass of approximately 103 kDa is expressed mainly in the thyroid gland and functions in thyroid hormone synthesis. Meanwhile Cytochrome P450 proteins like CYP2C9 are involved in drug metabolism and are expressed in the liver. Some proteins like ER and AR serve as nuclear hormone receptors playing key roles in gene transcription following ligand binding.
Biological function summary
These targets constitute essential components in cellular and physiological contexts. Estrogen and Androgen receptors enable hormone-driven transcription modulation integral to reproductive tissue function. PPAR gamma acts within adipose tissue regulating fatty acid storage and glucose metabolism and often intersecting with metabolic diseases. CYP2C9 and related enzymes metabolize xenobiotics and endogenous compounds influencing drug clearance rates. PXR can heterodimerize with Retinoid X Receptor to regulate genes responsible for detoxifying cells from foreign substances.
Pathways
These targets integrate into critical biological circuits. Estrogen Receptor and Androgen Receptor partake in steroid hormone signaling pathways important for the development and maintenance of secondary sexual characteristics. Similarly PPAR gamma aligns with the metabolic signaling pathway interacting with proteins involved in lipid metabolism and insulin sensitivity. Cytochrome P450 family members like CYP2C9 impact pathways related to drug metabolism working closely with other CYP enzymes to metabolize substrates including medications and hormones.
These proteins hold associations with various health conditions. Dysregulation of Estrogen Receptor or Androgen Receptor functions can contribute to hormone-sensitive cancers such as breast and prostate cancer respectively interacting with co-regulators like steroid receptor coactivators. PPAR gamma mutations link to metabolic disorders including type 2 diabetes and obesity due to its role in regulating insulin sensitivity. Changes in CYP2C9 activity can influence drug efficacy and lead to adverse drug reactions relevant in personalized medicine approaches with connections to other CYP family members concerning drug-drug interactions.