Abcam, ab141228, BAY 11-7082, IkappaBalpha kinase inhibitor

Size: 10mg / 50mg
MW 207.25 Da, Purity >99%. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
CAS number:19542-67-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:207.25 Da,
Molecular formula:C10H9NO2S,
PubChem:5353431,
Nature:Synthetic,
Solubility:Soluble in ethanol to 50 mMSoluble in DMSO to 100 mM,
Biochemical name:(E)-3-Tosylacrylonitrile,
Canonical smiles:CC1=CC=C(C=C1)S(=O)(=O)C=CC#N,
Isomeric smiles:CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N,
InChi:InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+,
InChiKey:DOEWDSDBFRHVAP-KRXBUXKQSA-N,
IUPAC Name:(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TDP1 also known as tyrosyl-DNA phosphodiesterase 1 is an important enzyme in DNA repair. Its molecular mass is approximately 68 kDa. TDP1 breaks phosphodiester bonds between DNA and tyrosine residues on trapped topoisomerase I resolving Top1-DNA complexes. This enzyme locates itself mainly in the nucleus of cells due to its role in dealing with DNA-related injuries. TDP1 ALDH1A1 and ROR gamma show widespread expression found in various tissues but most notably in neurons and hepatic tissues.
Biological function summary
TDP1 and similar proteins are involved in safeguarding genetic integrity by repairing damaged DNA. TDP1's activity is independent but collaborates within multi-protein complexes to enhance DNA repair efficiency. ALDH1A1 or aldehyde dehydrogenase 1 family member A1 functions primarily in aldehyde metabolism and detoxification processes while playing a plausible role in stem cell differentiation. ROR gamma also known as RAR-related orphan receptor gamma influences gene expression regulating immune response and circadian rhythms.
Pathways
These proteins find themselves within key biological routes. TDP1 operates in the single-strand break repair pathway important for correcting errors following replication stress and it interacts with PARP1 which is essential for chromatin regulation during repair. ALDH1A1 is part of the retinoic acid pathway impacting cell differentiation and development while ROR gamma plays a significant role in the NF-kappa B signaling pathway especially influencing immune system functionality.
The malfunction or alteration of these proteins can trigger various conditions. TDP1 mutations relate to neurodegenerative disorders such as SCAN1 where an impaired repair pathway leads to neuronal cell death. ALDH1A1 is connected to cancer progression particularly in stem-like cells of certain tumors and alterations in this protein can affect tumor growth and chemoresistance. ROR gamma has ties to autoimmune diseases such as psoriasis and rheumatoid arthritis as it regulates Th17 cell differentiation and interleukin production.