Abcam, ab141271, Epothilone B, Microtubule stabilizing agent

Size: 10µg / 100µg
MW 507.7 Da, Purity >98%. Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.
Key facts
CAS number:152044-54-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:507.7 Da,
Molecular formula:C27H41NO6S,
PubChem:448013,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mM,
Biochemical name:Epothilone B,
Biological description:Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.,
Canonical smiles:CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C,
Isomeric smiles:C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C,
InChi:InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1,
InChiKey:QXRSDHAAWVKZLJ-PVYNADRNSA-N,
IUPAC Name:(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PMP22 also known as Peripheral Myelin Protein 22 is a critical membrane protein involved in the myelination process within the peripheral nervous system. This protein has a mass of approximately 22 kDa. PMP22 is produced mainly in Schwann cells which are responsible for the formation of myelin sheaths around nerve fibers. It plays a role in maintaining the structural integrity and function of these myelin sheaths.
Biological function summary
PMP22 contributes to the regulation of cell growth and apoptosis ensuring proper nerve function and repair. It is not usually part of larger protein complexes but interacts significantly with myelin-associated proteins to stabilize the nerve structure. The protein also supports the adhesion among Schwann cells which helps in maintaining the compactness of the myelin sheath.
Pathways
PMP22 engages primarily in the myelination pathway and is essential for neuronal signaling. It interacts with proteins like MPZ (Myelin Protein Zero) which also takes part in myelin sheath integrity. PMP22 influences axonal function and communicates signals that support myelin maintenance and regeneration. Disturbances in these pathways can lead to compromised nerve conduction and peripheral neuropathies.
Mutations or overexpression in PMP22 are connected to Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with Liability to Pressure Palsies. These conditions reflect the critical role of PMP22 in nerve function where its interactions with proteins like Connexin32 become significant. Abnormalities in PMP22 can lead to demyelination resulting in nerve damage and the clinical manifestations associated with these neuropathies.