Abcam, ab141303, SF1670, PTEN inhibitor

Size: 5mg
MW 307.3 Da, Purity >98%. Selective PTEN inhibitor (IC 50 = 2 μM). Elevates intracellular PIP3 signaling. Reduces neutrophil functions, including phagocytosis, oxidative burst, polarization, and chemotaxis. Active in vivo .
Key facts
CAS number:345630-40-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:307.3 Da,
Molecular formula:C19H17NO3,
PubChem:9926586,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:PTP CD45 Inhibitor,
Biological description:Selective PTEN inhibitor (IC50 = 2 μM). Elevates intracellular PIP3 signaling. Reduces neutrophil functions, including phagocytosis, oxidative burst, polarization, and chemotaxis. Active in vivo.,
Canonical smiles:CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O,
InChi:InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23),
InChiKey:VZQDDSYKVYARDW-UHFFFAOYSA-N,
IUPAC Name:N-(9,10-dioxophenanthren-2-yl)-2,2-dimethylpropanamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD45RO also known as protein tyrosine phosphatase receptor type C is an isoform of the CD45 molecule weighing approximately 180 kDa. It functions by modulating signal transduction in immune cells achieved through dephosphorylation of specific tyrosine residues. CD45RO is expressed on memory T cells and is responsible for T cell activation processes. Cathepsin L alternatively named MEP is a cysteine protease involved in protein catabolism and is present in lysosomes of various tissues. Vitamin D Receptor (VDR) binds vitamin D metabolites and mediates their biological effects with its expression seen in cells of the small intestine kidneys and bone. DNA Polymerase iota is an enzyme involved in DNA replication and repair particularly within the nucleus. Lck or lymphocyte-specific protein tyrosine kinase is a member of the Src family kinases localized mainly in T cells. TDP1 also known as tyrosyl-DNA phosphodiesterase 1 is important for DNA repair pathways. PTPN13 widely known as FAP-1 is a phosphatase prominent in signal regulation. Cathepsin S participates in Class II MHC antigen processing. GALK1 is an important enzyme in galactose metabolism and Nrf2 is a transcription factor regulating antioxidant responses. IDH1 or isocitrate dehydrogenase 1 is significant for cellular metabolism and is central to the Krebs cycle.
Biological function summary
CD45RO functions in immune cell signal transduction and helps memory T cells quickly respond to pathogens. Cathepsin L participates in protein degradation and activation of certain peptides. The Vitamin D Receptor plays a role in regulating calcium and phosphate levels in the bloodstream while DNA Polymerase iota contributes to DNA fidelity during replication and repair. Lck supports T cell receptor signaling and facilitates immune response. TDP1 functions in fixing DNA single-strand breaks. In addition PTPN13 influences cell death and survival signaling pathways. Cathepsin S assists with antigen presentation essential for immune response. GALK1 is vital for converting galactose into glucose-1-phosphate. Nrf2 initiates transcription for protective enzymes and IDH1 helps regulate citric acid cycle metabolism.
Pathways
CD45RO plays a role in the T cell receptor signaling pathway by modulating Lck activity. Cathepsin L is involved in lysosomal protein degradation pathways and also associates with VDR in metabolic control processes. The Vitamin D Receptor is important in mineral ion homeostasis pathways. DNA Polymerase iota participates in DNA damage tolerance pathways interacting with other repair enzymes. Lck has essential roles in T cell antigen receptor signaling pathways. TDP1 functions in DNA repair pathways particularly interacting with other DNA repair proteins. PTPN13 is a negative regulator of Fas receptor-mediated apoptosis pathways. Cathepsin S participates in MHC class II antigen processing pathways. GALK1 is part of the Leloir pathway of galactose metabolism. Nrf2 activation triggers antioxidant response pathways. IDH1 plays a role in the oxidative decarboxylation within metabolic pathways.
CD45RO has connections to autoimmune diseases like rheumatoid arthritis as its alterations can lead to improper T cell activation. Cathepsin L links to cancer metastasis due to its role in tissue remodeling and degradation interacting with other proteases like Cathepsin S. Vitamin D receptor dysfunction is associated with osteomalacia affecting bone mineralization. DNA Polymerase iota when dysregulated may contribute to cancer genetics due to its role in DNA replication errors. Lck malfunction can lead to severe combined immunodeficiency impacting T cell development. TDP1 mutations relate to neurodegenerative disorders like spinocerebellar ataxia with axonal neuropathy. PTPN13 aberrations have implications in colorectal cancer given its signaling regulation influence. Cathepsin S has connections to autoimmune diseases interacting with immune system proteins. GALK1 deficiencies lead to galactosemia affecting carbohydrate metabolism. Nrf2 is involved in prostate cancer given its role in antioxidant defense. Mutant IDH1 is implicated in gliomas impacting cellular metabolism.