Abcam, ab141312, Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor

Size: 100mg
MW 219.2 Da, Purity >99%. Nitric oxide synthase inhibitor (K i = 4.4 μM). Cardiovascular effects. Active in vivo .
Key facts
CAS number:2149-70-4,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:219.2 Da,
Molecular formula:C6H13N5O4,
PubChem:440005,
Nature:Synthetic,
Solubility:Soluble in water to 5 mM,
Biochemical name:Nitroarginine,
Biological description:Nitric oxide synthase inhibitor (Ki = 4.4 μM). Cardiovascular effects. Active in vivo.,
Canonical smiles:C(CC(C(=O)O)N)CN=C(N)N[N+](=O)[O-],
Isomeric smiles:C(C[C@@H](C(=O)O)N)CN=C(N)N[N+](=O)[O-],
InChi:InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1,
InChiKey:MRAUNPAHJZDYCK-BYPYZUCNSA-N,
IUPAC Name:(2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Endothelial nitric oxide synthase (eNOS) inducible nitric oxide synthase (iNOS) and the Prostaglandin E Receptor EP2 (PTGER2) represent a diverse group of proteins with significant roles in various physiological processes. eNOS also known under the names NOS3 is primarily localized in endothelial cells and weighs approximately 133 kDa. It catalyzes the production of nitric oxide (NO) from L-arginine. Meanwhile iNOS is expressed in macrophages and some vascular cells and plays a role in immune responses. PTGER2 on the other hand is a receptor for prostaglandin E2 expressed in numerous tissues including the brain and kidneys. Each entity has a distinct function but shares interrelated pathways.
Biological function summary
These proteins and receptors influence various cellular functions and behavior. eNOS produces NO which acts as a signaling molecule facilitating vasodilation and influencing vascular tone. iNOS becomes activated during inflammatory responses and contributes to immune defense by producing NO. PTGER2 a G-protein-coupled receptor mediates the actions of prostaglandin E2 influencing processes like inflammation and vasodilation. While these proteins and receptors do not form a single complex they function collaboratively or independently within the cellular environment.
Pathways
The roles played by eNOS iNOS and PTGER2 integrate into broader biological networks. eNOS and iNOS are integral parts of the nitric oxide signaling pathway where NO interacts with guanylate cyclase to influence vascular smooth muscle relaxation. PTGER2 connects to the prostaglandin signaling pathway regulating complex physiological responses. These pathways often intersect sharing links with proteins such as cyclooxygenase-2 (COX-2) and guanylate cyclase important in modulating inflammation and vascular homeostasis.
The functions of eNOS iNOS and PTGER2 contribute to various pathological conditions. Dysfunction of eNOS often related to reduced NO availability associates with cardiovascular disorders including hypertension and atherosclerosis. Dysregulation of iNOS expression links to chronic inflammatory states such as rheumatoid arthritis. PTGER2's role in inflammation and vascular regulation connects it to disorders including inflammatory bowel disease interacting with proteins like COX-2 potentiating chronic inflammation. These interactions highlight both potential therapeutic targets and areas for further research.