Abcam, ab141354, Carbamoylcholine chloride (Carbachol), Cholinergic agonist

Size: 1g
MW 182.65 Da. Non-selective cholinergic agonist. Cholinesterase resistant. Blocks apoptosis. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
CAS number:51-83-2,
Form:SolidSee storage information,
Molecular weight:182.65 Da,
Molecular formula:C6H15N2O2.Cl,
PubChem:5831,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Carbachol,
Biological description:Non-selective cholinergic agonist. Cholinesterase resistant. Blocks apoptosis.,
Canonical smiles:C[N+](C)(C)CCOC(=O)N.[Cl-],
InChi:InChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H,
InChiKey:AIXAANGOTKPUOY-UHFFFAOYSA-N,
IUPAC Name:2-carbamoyloxyethyl(trimethyl)azanium;chloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Acetylcholinesterase also known as AChE is an enzyme with a molecular mass typically around 68 kDa. It is mainly expressed in the neuromuscular junctions and central nervous system where it plays a critical role in breaking down acetylcholine into acetate and choline stopping the signal transmission across a synapse. The target also includes muscarinic acetylcholine receptors such as CHRM1 CHRM2 CHRM3 CHRM4 and CHRM5 as well as nicotinic acetylcholine receptors subunits like CHRNA4 CHRNA7 CHRNB2 CHRNA10 CHRNA2 CHRNB3 CHRNB4 and CHRNA9. These receptors are expressed in various tissues including the brain heart and other peripheral organs.
Biological function summary
These proteins and complexes play significant roles in mediating cholinergic transmission. The muscarinic receptors are integral to G-protein coupled receptor complexes modulating responses such as cardiac rhythm or glandular secretion. Nicotinic receptors on the other hand form ion channels that regulate neurotransmitter release and are important in cognitive processes and neuromuscular function. Acetylcholinesterase assists in clearing acetylcholine from synaptic clefts to reset the signaling pathway and prevent continuous stimulation making this enzyme vital in synaptic signaling.
Pathways
Acetylcholinesterase and the cholinergic receptors are part of the cholinergic signaling pathway and neurotransmitter pathway. These pathways are essential for various physiological functions including muscle contraction and memory formation. Nicotinic acetylcholine receptor subunits like CHRNA4 and CHRNB2 are known for their roles in the dopaminergic pathway which links them to dopamine metabolism and transporters. Additionally the muscarinic receptors CHRM1 and CHRM5 integrate into the signal transduction and contribute to intracellular calcium regulation and MAP kinase activity.
Dysfunction in these targets can relate to Alzheimer's disease and myasthenia gravis. Alzheimer's is associated with a decrease in acetylcholinesterase activity impacting synaptic transmission and memory. Muscarinic acetylcholine receptors particularly CHRM2 and CHRM3 also have links to neurodegenerative processes. Nicotinic receptors like CHRNA4 and CHRNB4 may play roles in addiction and mood disorders by influencing dopaminergic activity. Understanding how these targets interact can illuminate their contributions to such diseases and potential therapeutic interventions.