Abcam, ab141475, Vinblastine sulfate, Microtubule dynamics inhibitor

Size: 5mg / 25mg
MW 909.1 Da, Purity >95%. Potent microtubule dynamics inhibitor. Inhibits tubulin addition (K i = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC 50 = 1 nM). Antitumor effects in vivo. .
Key facts
CAS number:143-67-9,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:909.1 Da,
Molecular formula:C46H58N4O9.H2O4S,
PubChem:241902,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Vincaleukoblastine sulfate,
Biological description:Potent microtubule dynamics inhibitor. Inhibits tubulin addition (Ki = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC50 = 1 nM). Antitumor effects in vivo.,
Canonical smiles:CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,
Isomeric smiles:CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,
InChi:InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1,
InChiKey:KDQAABAKXDWYSZ-JKDPCDLQSA-N,
IUPAC Name:methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1959 Vinblastine Sulfate. 1959-25 is the same size as the 25 mg size of ab141475.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tubulin is a family of globular proteins and essential components of microtubules which play an important role in maintaining cellular structure and facilitating intracellular transport. The beta-tubulins including beta III beta I beta IV beta II and alpha tubulin have molecular masses ranging around 50 kDa. Tubulin proteins are expressed in various tissues with beta-tubulin III expressing highly in neurons. Alternate names for tubulin include TUBA1C TUBA1A TUBB2A TUBB8 TUBB2B TUBB6 and TUBA3E. These proteins contribute to the assembly of microtubules influencing their dynamics and stability.
Biological function summary
Tubulin proteins form part of the microtubule complex which is fundamental to cellular processes such as mitosis and intracellular transport. These proteins influence microtubule dynamics important in chromosome segregation and signaling pathways involving cell movement and division. Tubulin interacts with various chemical structures such as vinblastine which affects microtubule polymerization. The dynamic instability of microtubules is important for their role in cell cycle progression and neuronal development.
Pathways
Tubulin family proteins participate in significant pathways like the mitotic spindle assembly and axonal transport. These pathways have implications in the regulation of cell cycle and neuronal functioning. Related proteins within these pathways include kinesins and dyneins which are motor proteins that transport cellular cargo along microtubules. The regulation of these pathways ensures proper cell division and neuronal signaling which are essential for organismal development and homeostasis.
Tubulin is linked with neurodegenerative diseases such as Alzheimer's disease and cancer. Tubulin dysfunction can impact microtubule assembly leading to errors in chromosome segregation and neuronal damage. Proteins connected to tubulin dysfunction include tau protein in Alzheimer's disease which aggregates and disturbs microtubule stability. In cancer aberrant tubulin activity may influence the effectiveness of chemotherapeutic agents targeting microtubule dynamics potentially impacting treatment outcomes.