Abcam, ab141527, Fumagillin, methionine aminopeptidase-2 (MetAP2) inhibitor

Size: 5mg
MW 458.5 Da, Purity >95%. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2) (IC50 = 9.2 nM). Anti-angiogenic. Inhibits endothelial cell proliferation. Inhibits neovascularization and reduces diet-induced obesity*in vivo*. Orally active.
Key facts
CAS number:23110-15-8,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:458.5 Da,
Molecular formula:C26H34O7,
PubChem:3430,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:10-[[5-Methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid,
Biological description:Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2) (IC50 = 9.2 nM). Anti-angiogenic. Inhibits endothelial cell proliferation. Inhibits neovascularization and reduces diet-induced obesity*in vivo*. Orally active.,
Canonical smiles:CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C,
InChi:InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28),
InChiKey:NGGMYCMLYOUNGM-UHFFFAOYSA-N,
IUPAC Name:10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months