Abcam, ab142099, Vandetanib, VEGFR2 tyrosine kinase inhibitor

Size: 10mg / 50mg
MW 475.4 Da, Purity >98%. Orally available, potent VEGFR2 tyrosine kinase inhibitor (KDR IC 50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC 50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC 50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Displays anti-angiogenesis activity.
Key facts
CAS number:443913-73-3,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:475.4 Da,
Molecular formula:C22H24BrFN4O2,
PubChem:3081361,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mMSoluble in ethanol to 10 mM,
Biochemical name:Vandetanib,
Biological description:Orally available, potent VEGFR2 tyrosine kinase inhibitor (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Displays anti-angiogenesis activity.,
Canonical smiles:CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC,
InChi:InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27),
InChiKey:UHTHHESEBZOYNR-UHFFFAOYSA-N,
IUPAC Name:N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions