Abcam, ab142148, FK-866, NAMPT inhibitor

Size: 1mg / 5mg
MW 391.5 Da, Purity >98%. Potent, selective, non-competitive NAMPT inhibitor (K i = 0.3 nM). Anticancer activity in vivo . Orally active.
Key facts
CAS number:658084-64-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:391.5 Da,
Molecular formula:C24H29N3O2,
PubChem:6914657,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mMSoluble in ethanol to 100 mM,
Biochemical name:Daporinad,
Biological description:Potent, selective, non-competitive NAMPT inhibitor (Ki = 0.3 nM). Anticancer activity in vivo. Orally active.,
Canonical smiles:C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3,
Isomeric smiles:C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3,
InChi:InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+,
InChiKey:KPBNHDGDUADAGP-VAWYXSNFSA-N,
IUPAC Name:(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-pyridin-3-ylprop-2-enamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1914 FK-866. 1914-5 is the same size as the 5 mg size of ab142148.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytochrome P450 3A4 also called CYP3A4 is an important enzyme in the liver and intestine. It plays an important role in metabolizing around half of all drugs currently used. CYP3A4 has a mass of approximately 57 kDa. It is expressed not only in the liver and intestinal tract but also present in significant amounts in the kidneys lungs and brain. This enzyme belongs to the cytochrome P450 family which includes other key proteins involved in drug metabolism like CYP3A5.
Biological function summary
The enzyme CYP3A4 facilitates the chemical breakdown of substances. It performs oxidation reactions that convert lipophilic drugs into a more water-soluble form aiding excretion from the body. CYP3A4 is not usually part of a larger enzyme complex but it works with cofactors in the liver like NADPH-cytochrome P450 reductase to perform its function. This cooperation is essential to its role in activating and deactivating drugs which prevents toxic accumulation of substances.
Pathways
CYP3A4 influences the metabolism of drugs and the synthesis of cholesterol and other steroids. It is involved in the xenobiotic metabolism pathway which includes other proteins such as CYP2C9 and CYP2D6. CYP3A4 metabolizes various substances including hormones and some vitamins. It impacts the homeostasis of endogenously generated compounds and indirectly affects signaling pathways that involve these compounds.
CYP3A4 has associations with liver diseases and drug-induced toxicity. It also relates to drug interactions as its activity can vary widely between individuals due to genetic polymorphisms affecting drug efficacy and safety. Changes in CYP3A4 expression or function can link to conditions like liver cancer. The enzyme's activity may also influence conditions involving inflammation through its connections to the metabolism of anti-inflammatory drugs and interaction with proteins such as P-glycoprotein.