Abcam, ab142177, ML130, NOD1 inhibitor

Size: 5mg / 25mg
MW 287.34 Da, Purity >97%. Potent, selective NOD1 inhibitor (IC 50 = 560 nM). Inhibits NOD1-induced NF-κB activation in vitro . Cell-permeable.
Key facts
CAS number:799264-47-4,
Purity:>97%,
Form:SolidSee storage information,
Molecular weight:287.34 Da,
Molecular formula:C14H13N3O2S,
PubChem:1088438,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 10 mM,
Biochemical name:Nodinitib-1,
Biological description:Potent, selective NOD1 inhibitor (IC50 = 560 nM). Inhibits NOD1-induced NF-κB activation in vitro. Cell-permeable.,
Canonical smiles:CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N,
InChi:InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16),
InChiKey:SRFABRWQVPCPRG-UHFFFAOYSA-N,
IUPAC Name:1-(4-methylphenyl)sulfonylbenzimidazol-2-amine

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1974 ML130. 1974-25 is the same size as the 25 mg size of ab142177.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interleukin-8 (IL-8) also known as CXCL8 is a chemokine with a mass of approximately 8 kDa. It plays a role in the immune response by attracting neutrophils to sites of inflammation. IL-8 is expressed in various cells including macrophages epithelial cells and airway smooth muscle cells. Another related target is NOD1 (nucleotide-binding oligomerization domain-containing protein 1) which senses bacterial peptidoglycans and helps trigger immune reactions.
Biological function summary
This family of proteins functions in the immune system to mediate inflammatory responses. IL-8 initiates the movement and activation of neutrophils while NOD1 acts as an intracellular pattern recognition receptor. Together they form part of a complex network that protects the body from infections by activating immune cells and promoting the production of cytokines.
Pathways
IL-8 and NOD1 participate in important signaling pathways that regulate immune response and inflammation. IL-8 is involved in the chemokine signaling pathway influencing other proteins like CXCR1 and CXCR2 receptors on leukocytes. NOD1 participates in the NF-κB pathway which involves proteins like RIP2 kinase playing a role in inflammatory signal transduction.
IL-8 and NOD1 have significant implications in various immune-related conditions. For IL-8 its overexpression often relates to chronic inflammatory diseases like rheumatoid arthritis. NOD1 is associated with inflammatory bowel disease where its activity contributes to intestinal inflammation. In these contexts IL-8 works alongside CXCR receptors while NOD1 interacts with RIP2 kinase to influence disease progression.