Abcam, ab142437, Gliotoxin, NF-kappaB inhibitor

Size: 5mg
MW 326.4 Da, Purity >98%. Specfic NF-κB inhibitor. Induces apoptosis and suppresses TNF-α gene expression in vitro . Farnesyltransferase and geranylgeranyltransferase I inhibitor (IC 50 = 80 and 17 μM respectively). Mycotoxin antibiotic. Immunosuppressive, anti-inflammatory and antitumor agent. Active in vivo and in vitro . Orally active.
Key facts
CAS number:67-99-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:326.4 Da,
Molecular formula:C13H14N2O4S2,
PubChem:6223,
Nature:Synthetic,
Solubility:Soluble in DMSOSoluble in ethanol,
Biochemical name:Gliotoxin,
Biological description:Specfic NF-κB inhibitor. Induces apoptosis and suppresses TNF-α gene expression in vitro. Farnesyltransferase and geranylgeranyltransferase I inhibitor (IC50 = 80 and 17 μM respectively). Mycotoxin antibiotic. Immunosuppressive, anti-inflammatory and antitumor agent. Active in vivo and in vitro. Orally active.,
Canonical smiles:CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O,
Isomeric smiles:CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O,
InChi:InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1,
InChiKey:FIVPIPIDMRVLAY-RBJBARPLSA-N,
IUPAC Name:(1R,7S,8S,11R)-7-hydroxy-11-(hydroxymethyl)-15-methyl-12,13-dithia-9,15-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,14-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF31 also known as HOIP (HOIL-1-interacting protein) is a part of the linear ubiquitin chain assembly complex (LUBAC). It has a mass of approximately 119 kDa and plays an essential role in protein ubiquitination processes. This protein is actively expressed in various tissues including the spleen lung and lymphoid tissues. RNF31 collaborates with other proteins like SHARPIN and RBCK1 to modulate cellular responses.
Biological function summary
RNF31 contributes to the regulation of NF-κB signaling which is an important player in inflammation and immune responses. It is an important component of the LUBAC complex facilitating the linear ubiquitination of target proteins. Its activity influences the activation of NF-κB transcription factors which are important for controlling the expression of genes linked to immune and inflammatory reactions.
Pathways
The RNF31 protein is integral to the NF-κB signaling pathway as well as to apoptosis. It mediates modifications on proteins that ultimately result in NF-κB activation maintaining a balance between survival and cell death. In these functions RNF31 is closely related to SUV39H1 and other partners within these pathways which collectively influence transcriptional activity and cellular fate.
RNF31 has connections with inflammatory diseases and certain types of cancer. Abnormal regulation or expression of RNF31 and its associated proteins like SHARPIN might contribute to pathological conditions by disrupting normal immune responses. Understanding these connections offers potential therapeutic targets for conditions such as rheumatoid arthritis and various carcinomas.